BELS Founding Membership is open to life science leaders who are special supporters wishing to assist the BELS organisation in moving forward more rapidly. Their championing of the BELS cause provides a leadership commitment to extend the UK’s heritage of scientific excellence in the spirit of collaboration, innovation and kinship. Join now as a Founding Member!
BELS gratefully acknowledges the generous contributions of our early Founding Members
Mark Bamforth, President & CEO, Brammer BioPharmaceuticals, Massachusetts
Dr Dominic P Behan, President & CEO, Beacon Discovery, Boston, Massachusetts
Dr Simon Blake, Sr Director, Scientific Licensing, Immunology, Janssen Research & Development, Berwyn, Pennsylvania
Dr Timothy P Clackson, President of R&D, Chief Scientific Officer, ARIAD Pharmaceuticals, Cambridge, Massachusetts
Nicola Downes, Chief Financial Officer, PneumRx (a BTG group company), San Francisco, California
Dr Christopher H Evans, PhD, DSc, Professor & Director of Rehabilitation Medicine Research Center at Mayo Clinic, Rochester, Minnesota
Dr Clive A Meanwell, Chief Executive Officer, The Medicines Company, Parsippany, New Jersey
Dr Stephen Naylor, Chairman & CEO, MaiHealth, Indianapolis, Indiana
Biographies of BELS Founding Members
Mark Bamforth, President & CEO, Brammer BioPharmaceuticals, Massachusetts USA
Mark Bamforth is the founder, President and CEO of Brammer Bio, a cell and gene therapy contract and development manufacturing organization, which merged with 10-year old Florida Biologix, a producer of early clinical materials for cell and gene therapies based in Florida with 120 employees. Brammer is developing a facility in Massachusetts to provide clients with phase III/commercial products, which will come on stream in early 2017.
In 2010, Mark founded and led Gallus BioPharmaceuticals, a premier CMO delivering biopharmaceuticals worldwide. Following the acquisition of a commercial facility in St. Louis with an experienced team of 160 and a supply agreement with Janssen, Gallus tripled through organic growth and a 2013 merger with another CMO, Laureate Biopharma. With Gallus’ investors, Mark managed the sale of Gallus to DPx Holdings B.V. in September 2014 and supported the integration of the two organisations.
Mark also has 22 years of previous experience in the UK and USA, running diverse, global manufacturing operations and a pharmaceutical CMO business for Genzyme, including supporting pioneering cell therapy and gene therapy clinical trials undertaken by Genzyme, resulting in the first FDA approval of a cell therapy facility and products in the late 1990s, and the establishment of dedicated gene therapy clinical capacity. He began his career as a petroleum engineer exploring for North Sea oil, then as a chemical engineer in the whisky industry.
Mark currently serves on the Board of MassBio and is a founding trustee of the Saltire Foundation, which enables young Scottish entrepreneurs to expand their business knowledge through education and internships with high growth companies in the US. He has a BS in Chemical Engineering from Strathclyde University and an MBA from Henley Management College. He lives in Cambridge, Massachusetts with his wife and two children.
Dr Dominic P Behan, President & CEO, Beacon Discovery, Boston, Massachusetts USA
Dominic has 23 years of experience in the pharmaceutical industry. His industrial career began at Neurocrine Biosciences where he directed several drug discovery programs from 1993-1997. In 1997 he co-founded Arena Pharmaceuticals, was elected to the Board of Directors in 2000, and most recently served as Executive Vice President and Chief Scientific Officer. He has participated in multiple private and public financing initiatives. He helped build Arena from conception into a globally recognized biotechnology organization that developed a robust pipeline of G protein-coupled receptor (GPCR) modulators, the first of which, BELVIQ® (lorcaserin HCl), was approved by the FDA in 2012 for chronic weight management. Dominic led the FDA advisory panel process that ultimately resulted in BELVIQ being the first drug in 13 years to be approved by the FDA for obesity and the first drug in its class of selective 5-HT2C agonists. He has worked actively with multiple global regulatory healthcare authorities, including the FDA.
Dominic has secured numerous pharmaceutical partnering collaborations with large multinational pharmaceutical companies such as Boehringer Ingelheim International GmbH, Eli Lilly, Ortho McNeil/Johnson & Johnson (JNJ), Merck, Eisai, Taisho as well as several biotechnology companies and academic institutions.
In 2016, Dominic co-founded Beacon Discovery, a privately held drug discovery incubator, where he now serves as President and CEO. He is also a consultant to Arena Pharmaceuticals where he chairs the Scientific Advisory Board. Dominic was included in the PharmaVOICE 100 list of the most inspiring people. He also serves on the Scientific Advisory Board of Keystone, a world renowned organization responsible for establishing and arranging meetings of scientific excellence, and has authored numerous publications and patents that address multiple therapeutic areas encompassing protein/neuropeptide mechanisms as well as small molecule modulation of CNS, neuroendocrine, cardiovascular and metabolic systems.
Dominic obtained a BSc Honors degree in Biochemistry from the University of Leeds and a PhD in Biochemistry from the University of Reading, investigating the biology of stress. He then spent three years as a Post-Doctoral Research Fellow at the Salk Institute in San Diego. He also received a higher doctorate (DSc) degree from the University of Reading where he was appointed Visiting Professor.
Dr Simon Blake, Sr Director, Scientific Licensing, Immunology, Janssen Research & Development, Berwyn, Pennsylvania USA
Simon Blake obtained his PhD in Biochemistry whilst at the Kennedy Institute of Rheumatology, London, UK. He then served multiple Post-Doctoral Research appointments, where he continued to study the pathogenesis of inflammatory joint disease, focusing on the role of the cytokines IL-1 and TNF. He moved into industry in 1994 spending five years each at Celltech Therapeutics and GlaxoSmithkline respectively, leading small and large molecule discovery research teams. In 2004 he joined Centocor and was appointed Director of Cardiovascular and Metabolic Diseases team in 2005. Simon is currently Senior Director for Scientific Licensing in Janssen Business Development, supporting the Immunology and Janssen Biotherapeutics teams within Janssen Pharmaceuticals R&D.
Dr Timothy P Clackson, President of R&D, Chief Scientific Officer, ARIAD Pharmaceuticals, Cambridge, Massachusetts USA
During his 20+ year career at ARIAD, an integrated oncology company headquartered in Cambridge, Massachusetts, Tim Clackson has held a series of increasingly senior positions, including CSO since 2003 and President of R&D since 2010. He has overall operational and strategic responsibility for R&D at ARIAD, including drug discovery, preclinical and translational research, clinical development, medical affairs, and technical operations. He led the multi-disciplinary R&D team that discovered and developed Iclusig (ponatinib), a pan-BCR-ABL inhibitor now approved in approximately 50 countries for the treatment of resistant CML and Ph+ALL; and investigational agents brigatinib (a next-generation ALK inhibitor currently under FDA review), AP32788 (an EGFR/HER2 inhibitor in phase 1/2 development), ridaforolimus (an mTOR inhibitor licensed to Medinol Ltd) and rimiducid (a small molecule regulator for cancer cell therapy licensed to Bellicum Pharmaceuticals). He also led the earlier development of a widely-used platform technology for small molecule “dimerizer” control of gene and cell activity.
From 1991 to 1994, Tim was a postdoctoral fellow at Genentech, where his studies with Dr James A Wells on growth hormone receptor defined the now-established “hot spot” paradigm for how proteins interact. He received his PhD in Biology from Cambridge University in 1991, for research conducted under Dr Greg Winter, FRS at the MRC Laboratory of Molecular Biology into antibody engineering and the development of antibody phage display technology, subsequently commercialized by Cambridge Antibody Technology. Tim has published approximately 100 scientific papers, book chapters and reviews, and is a co-inventor on 15 issued US patents. In addition to receiving his PhD from Cambridge University in 1991, he received his BA in Biochemistry from Oxford University in 1987. He was born in the UK, currently resides in Lexington, Massachusetts, and enjoys dual UK and US citizenship.
Nicola Downes, Chief Financial Officer, PneumRx (a BTG group company), San Francisco, California USA
Nicola Downes has been managing the Finance Department at PneumRx since 2006. PneumRx, a leader in the field of interventional pulmonology, was acquired by London-based BTG PLC in 2014. Nicola has worldwide experience in managing all aspects of Accounting and Finance.
Previous to PneumRx, she served as the Chief Financial Officer for ArkaSoft, a Silicon Valley software firm. She has held senior accounting and supervisory positions for a variety of firms prior to that, including Hansa Chemie AG, the Royal Navy, UK, a Lloyds of London syndicate, as well as Auditor with Accenture and Price Waterhouse Coopers.
Nicola is a Chartered Certified Accountant. She received her BA in Accounting and Finance from University of Brighton, UK and her MBA from Oxford Institute of International Finance, UK.
Dr Christopher H Evans, PhD, DSc, Professor & Director of Rehabilitation Medicine Research Center at Mayo Clinic, Rochester, Minnesota USA
Christopher Evans, a leader in the field of gene therapy in the treatment of arthritis, is Director of the Rehabilitation Medicine Research Center at Mayo Clinic. He is also Maurice Müller Professor of Orthopaedic Surgery Emeritus at Harvard Medical School.
Trained in molecular biology in the United Kingdom, Chris became the inaugural Henry Mankin Professor of Orthopaedic Surgery and Professor, Department of Molecular Genetics and Biochemistry, at the University of Pittsburgh Medical School. While at the University of Pittsburgh, he obtained an MA in the History and Philosophy of Science. In 1994, he was awarded a DSc by the University of Wales, UK. Recruited to Harvard Medical School in 1999, he held the Robert Lovett Chair and then the Maurice Müller Chair of Orthopaedic Surgery. He was recruited to Mayo Clinic in 2013.
Chris’ research interests focus on the application of biological therapies, particularly gene therapy, to the treatment of disorders of bones and joints, a field he pioneered. He was principal investigator for the world’s first arthritis gene therapy trial.
Dr Clive A Meanwell, Chief Executive Officer, The Medicines Company, Parsippany, New Jersey USA
Clive Meanwell is the Founder and Chief Executive Officer of The Medicines Company. From September 2001 to August 2015, he was also chairman of the board. Under his guidance the company has built a reputation as an innovative institution known for developing industry-leading, value-based products to treat cardiovascular disease, infectious disease and sedation. He was previously a partner and managing director at MPM Capital, LP and, before that, held key positions at F Hoffmann-La Roche, Inc, including Senior Vice President at Roche Biosciences in Palo Alto, and leadership roles at Roche’s Basel, Switzerland, headquarters. Clive received his MD cum laude and MB, ChB and PhD from the University of Birmingham, UK.
He was recently awarded the 2016 Dr Sol J Barer Award for Vision, Innovation, and Leadership. Named for Sol J. Barer, PhD, founder and former Chairman and Chief Executive Officer of Celgene Corporation of Summit, New Jersey, the award recognizes outstanding research and business leaders who have made significant contributions to the growth and prosperity of the biosciences industry in New Jersey and throughout the world.
Dr Stephen Naylor, Chairman & CEO, MaiHealth, Indianapolis, Indiana USA
Stephen Naylor is currently Founder, Chairman and CEO of the preventive medicine company MaiHealth based in Indianapolis. He has over 25 years of experience in the Health and Life Sciences in both the academic and private sectors. In addition, he is also the founder and served as Executive Management /Chairman of numerous other companies in the personalised medicine, diagnostic, companion diagnostic, biomarker and systems biology sectors.
Steve has published over 250 scientific journal manuscripts, filed over 20 patents and helped raise in excess of $40 million in federal grants (NIH/SBIR) and $40 million in equity investments for the companies he has been associated with over the past decade. Stephen has degrees from the University of East Anglia (BSc-1st Class Honors-Chemistry), University of Southampton (MSc-Oceanography), University of California (MS-Chemical Sciences) and University of Cambridge (PhD-Analytical Biochemistry /Chemistry) and also was a Postdoctoral Fellow at MIT. Over the years he has worked at the MRC (UK), Mayo Clinic (US) and the world’s first systems biology company Beyond Genomics, as well as helped found numerous small start-up entities, all in the US.
Please contact Nigel Gaymond if you would like more information on joining BELS as a Founding Member, or if you would like to explore other opportunities to support the organisation.